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These differences in the clinical signi?cance of Pin1overexpression may be rationalized considering the provocative hypothesis that inbreast cancer the mutant p53 network may be the major determinant of aggressive-ness among the oncogenic mechanisms ampli?ed by Pin1, while in other tumortypes, other mutant p53-independent mechanisms may take over. The problem is thatwe are constrained by abnormal lung mechanicsand the natural history of the condition

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Note that the problem, as presented, addresses issuesof theory, method, and application.

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As is seen with positive pressure ventila-tion in the normal lung, the increase in pleuralpressure with PEEP will reduce venous return tothe right heart in ARDS (Dhainaut et al.

The knots can be extraluminally or intraluminally tied.The remaining portion of the anastomosis is sewn with full thickness bites, inverting themucosa. This device also can deploy absorbable copolymerLactomer staples in the 55-mm length version

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With light of wavelength 540 nm(see Table 1.1), a green-filtered light to which the eye isextremely sensitive, and with appropriate objective andcondenser lenses, the greatest attainable resolving powerof a bright-field microscope would be about 0.2

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xm (seeFolder 1.4, page 13 for method of calculation). (Note: If surgeon preference is a CTfor imaging confirmation of disk site, this premedication may provide heavy enoughsedation where general anesthesia is unnecessary for CT.) Intraoperatively, opioid, ket-amine, and lidocaine CRIs work nicely to manage noxious stimuli. Management ofacute organophosphate pesticide poisoning.

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